An overview of the synaptic vesicle lipid composition

Chemical neurotransmission is the major mechanism of neuronal communication. Neurotransmitters are released from secretory organelles, synaptic vesicles (SVs) via exocytosis into cleft. Fusion SVs with presynaptic plasma membrane balanced by endocytosis, thus maintaining at steady-state levels. The protein machineries responsible for exo- and endocytosis have been extensively investigated. In contrast, less known about role lipids in transmission how lipid composition affected dynamic exo-endocytotic cycling. Here we summarize current knowledge composition, organization, function SV lipids. We also cover biogenesis maintenance during vesicle cycle.